HHMI Bulletin: Leptin's Legacy

From: Subject: HHMI Bulletin: Leptin's Legacy Date: Wed, 19 Nov 2008 14:54:22 -0600 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C94A56.B53370E0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3350 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C94A56.B53370E0 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.hhmi.org/bulletin/mar2003/leptin/leptin2.html HHMI Bulletin: Leptin's Legacy

=20

Scientists, of course, approach any notion of = a magic=20 bullet with supreme skepticism, if not total = disdain.=20 But electrified by leptin's potential for the = treatment=20 of obesity=97the mice had lost 30 percent of = their body=20 weight in just two weeks=97business pounced on = the=20 discovery. With more than half of U.S. adults = overweight=20 or obese, a cure would be a major advance in = public=20 health. Moreover, the treatment was sure to be a = cash=20 cow for its marketers. The biotech company Amgen = paid=20 $20 million to license the hormone.

When Amgen sponsored a large clinical trial = of=20 leptin, however, few participants lost weight, = dashing=20 hopes that the hormone could curb obesity. = "Treatment=20 with high-dose leptin did not achieve the = clinical or=20 commercial hurdles necessary," says Amgen = spokesperson=20 Christine Brown. "The company is not looking = further at=20 using leptin in normal adult obesity."

That first look at leptin might have stopped=20 everything, but scientists kept digging. They = had=20 compelling reasons to persist, such as = Friedman's=20 dramatic finding that leptin also lowered = resistance to=20 insulin in those obese mice.

Today, studying leptin's role in metabolism = while=20 continuing to explore its therapeutic = possibilities,=20 Friedman and others are beginning to piece = together the=20 mechanisms through which the hormone affects = several=20 systems in the body. And, importantly, leptin = has been=20 found to treat successfully=97possibly even = cure=97two rare=20 diseases: a defect in the leptin gene and = lipodystrophy,=20 a disease caused by the absence of fat cells, = which the=20 body relies on to make leptin.

ADJUSTING THEIR=20 SIGHTS
Stephen O'Rahilly, an = endocrinologist=20 at the University of Cambridge, has given leptin = supplements to extremely obese children who have = a=20 defective leptin gene. The children, he says, = "are=20 constantly hungry, are eating frozen food = without=20 thawing it. Their lives are dominated by the = search for=20 food." Treatment with leptin, he adds, is = "utterly=20 dramatic. With a once-a-day injection, you are=20 essentially taking almost wheelchair-bound = children and=20 changing them into near-normal children." Elif = Oral (now=20 at the University of Michigan) and her = colleagues at the=20 National Institute of Diabetes and Digestive and = Kidney=20 Diseases (NIDDK) achieved similarly remarkable = results=20 by using leptin to treat lipodystrophy (see Proof=20 Positive).

Perhaps equally important may be leptin's = impact on=20 insulin for some people with type 2 diabetes. = "It's very=20 clear in a number of settings that leptin can = improve=20 diabetes," Friedman remarks. "Its usefulness is = not=20 limited to lipodystrophy patients."

Thus, even though leptin did not live up to = initial=20 expectations that it would cure obesity, it has = since=20 proved to be an invaluable research and = therapeutic=20 tool. Peter J. Havel, a nutrition researcher at = the=20 University of California, Davis, says that by=20 "demonstrating that body weight is a = physiological=20 parameter regulated by hormones, leptin opened = up the=20 whole field of obesity research." Leptin = experiments,=20 O'Rahilly adds, have debunked the notion that = obesity=20 results from people's "immorality, behavior and=20 gluttony."

RESISTANCE VERSUS=20 DEFICIENCY
The leptin story began in = 1950,=20 when researchers at The Jackson Laboratory in = Bar=20 Harbor, Maine, noticed that they had a strain of = mice=20 that were obese, lethargic, insulin-resistant = and=20 constantly hungry. This so-called ob/ob = mouse,=20 Friedman says, "lives in a state of perceived=20 starvation, so ironically it becomes fat." The=20 scientific explanation finally emerged in 1994, = when=20 Friedman and his colleagues found the mutated = ob=20 gene responsible for the syndrome. The next = year, they=20 purified the normal ob gene's product, a = hormone=20 they dubbed leptin for the Greek word = lept=F3s,=20 which means "thin." When they gave the obese = mice leptin=20 supplements, the animals lost weight, became = more active=20 and began responding to insulin.

At first, leptin seemed to be simply a signal = sent by=20 fat cells to the brain: "We're full. Stop = eating." But=20 as leptin research took off=97the hormone has = been the=20 subject of more than 4,200 scientific papers = since=20 1995=97the picture became more complicated. = Scientists=20 found large numbers of leptin receptors on the=20 hypothalamus, a brain structure known to control = appetite. Many other effects of leptin=97or the = absence of=20 leptin=97seem to work through the blood, = Friedman=20 explains, adding that the hormone "modulates T = cells,=20 macrophages, platelets and a whole host of other = physiological systems" (see Weight= =20 Regulation and Then Some).

In retrospect, it seems clear why so many = people in=20 the Amgen clinical trial failed to lose weight, = says=20 Friedman. Obese people have many fat cells, and = they=20 generally make lots of leptin. Therefore, = obesity=20 results more often from a failure to respond to = leptin=20 than from an absence of leptin.

Although most people in the trial may have = had=20 sufficient leptin, a subset was probably = deficient in=20 the hormone, says Friedman. "Fifteen to 20 = percent of=20 the obese people [in the study] did in fact lose = significant amounts of weight. A key unresolved = issue=20 concerns the plasma level of the hormone below = which a=20 robust biologic response can be predicted," he = adds.=20

"I don't want to protest too much, but it's = as if we=20 found that the majority of adult-onset diabetics = don't=20 respond to insulin, and concluded that insulin = has=20 nothing to do with lowering glucose." In other = words,=20 leptin resistance in the majority of = participants may=20 have masked leptin deficiency in the minority. = Friedman=20 and his colleagues are now trying to identify = obese=20 people who have low concentrations of leptin and = might=20 therefore benefit from supplements.

To treat leptin resistance, scientists must = have a=20 better understanding of the signaling pathways = activated=20 by the hormone. Studies of two components of = those=20 pathways were published in = 2002.

Weight = regulation and=20 then some...






	Proof=20 Positive

Friedman and James M. Ntambi, a biochemist at = University of Wisconsin-Madison, measured the = effect of=20 leptin on the expression of 12,000 genes that = seem to be=20 active in the liver. The biggest change occurred = in the=20 expression of the gene that makes an enzyme = called=20 stearoyl-CoA desaturase-1 (SCD-1). SCD-1 helps = determine=20 whether the body stores fat or burns it. When = the=20 researchers removed the gene for SCD-1 from = their=20 ob/ob mice, they discovered that the = animals'=20 metabolism returned almost to normal. Even = though the=20 mice made no leptin, they were not obese. = Moreover, says=20 Ntambi, "these animals are more = insulin-sensitive and=20 don't become diabetic." The results help show = how leptin=20 works. "For years the mechanism was a black = box," says=20 Ntambi. "Now we know that SCD-1 is on one = pathway of=20 leptin's actions."

Barbara B. Kahn, an endocrinologist at = Harvard=20 Medical School and Beth Israel Deaconess Medical = Center=20 in Boston, reported on a different leptin = pathway=20 involved in fatty acid metabolism in muscle. = Like=20 Ntambi, she says her study shows that pathway = research=20 may lead to drugs that improve leptin's = efficiency by=20 sidestepping resistance to the hormone and = activating=20 molecules further along the signaling pathway. =

PREVENTING=20 STARVATION
"There are a lot of = interesting=20 hypotheses [about leptin] out there," says = Phillip=20 Gorden, former director of NIDDK, who now does = research=20 there. "Some people think it's a protective = mechanism=20 against starvation, some think it's a satiety = signal and=20 some think its major role is to control lipid=20 distribution," directing the body to store fat = in fat=20 cells rather than in, say, the liver, where fat = deposits=20 are linked to disorders such as diabetes.

The many, seemingly unrelated effects of = leptin,=20 Friedman says, may have evolved to provide a = "link=20 between the nutritional state and the physiology = and=20 behavior of an animal," enabling it to adapt to=20 starvation. The fact that one fat-derived = molecule=20 affects metabolism, reproduction and immune = status may=20 represent evolutionary efficiency, he adds. = "Leptin is=20 designed to measure the amount of fat you carry, = and=20 once you have a molecule that can signal that, = it's=20 logical that it would send that signal to a = number of=20 physiologic systems."

The leptin gene apparently conferred a = selective=20 advantage on our ancestors by enabling them to = survive=20 lean times. These days, the challenge in = developed=20 societies is to remain lean during flush times: = Obesity=20 and diabetes are far more threatening than = starvation.=20 Indeed, studies emanating from the discovery of = leptin=20 emphasize how hard it is to lose weight. Randy = J.=20 Seeley, a neuroscientist at the University of = Cincinnati=20 who studies appetite regulation in the brain, = points to=20 the melanocortins, a group of leptin-sensitive=20 neuropeptides that help regulate energy balance. = Although drugs that target the melanocortins = might=20 result in lower food intake, he says, the = control of=20 food intake is complicated and inclined toward = storing,=20 not burning, fats. "You were not built to lose = weight,=20 you were built to not starve to death."

Although leptin was not a magic bullet for = obesity,=20 many researchers say the discovery of the = hormone has=20 changed forever the study of obesity, diabetes = and=20 metabolism. "Leptin was so successful in the = rodent=20 model that people immediately became excited = about it as=20 an obesity treatment factor," says Gorden. "In = reality,=20 that was probably an enormous leap of faith." =

Still, Gorden adds, leptin's ability to = treat=97and=20 possibly cure=97two rare diseases has renewed = hope that=20 it, or a compound discovered through it, may = help treat=20 obesity, diabetes and other devastating = metabolic=20 disorders. Leptin, he says, "offers a window of=20 opportunity that we didn't have before."

Friedman says the window is wide open, and in = the=20 February 7, 2003, issue of Science, he = called for=20 a large effort aimed at understanding the = biology of=20 obesity. Now that a molecular framework of the = system=20 that regulates body weight is in hand, he says, = it's=20 time to define the genetic differences between = lean and=20 obese and figure out how environmental and = developmental=20 factors alter the function of this system. Only = from=20 this, he says, will come rational therapies to = combat=20 obesity and its complications.

Download= =20 this story in Acrobat PDF format.
(requires = Acrobat Reader)

Illustration: The Friedman = Lab
Photo:=20 Marc Bryan-Brown

Reprinted from the HHMI = Bulletin,=20
March 2003, pages 24=9627.
=A92003 Howard = Hughes=20 Medical Institute



Jeffrey Friedman is now = looking=20 at genetic factors in obesity.

Jeffrey= =20 Friedman's Research Abstract The=20 Friedman Lab




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Verdana, Arial, San Serif } .darkbrown B { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #796a55; FONT-FAMILY: = Verdana, Arial, San Serif } .darkbrown I { FONT-SIZE: 12px; COLOR: #796a55; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif } A.mediumgrey B { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #999999; FONT-FAMILY: = Verdana, Arial, San Serif } A.mediumgrey { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #999999; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.mediumgrey:hover { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #0aa5d2; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.mediumgrey:hover B { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #0aa5d2; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } .crosslink { FONT-WEIGHT: normal; FONT-SIZE: 10px; TEXT-TRANSFORM: uppercase; COLOR: = #0aa5d2; FONT-FAMILY: Verdana, Arial, San Serif } A.crosslink { FONT-WEIGHT: normal; FONT-SIZE: 10px; TEXT-TRANSFORM: uppercase; COLOR: = #0aa5d2; FONT-FAMILY: Verdana, Arial, San Serif; TEXT-DECORATION: none } A.crosslink:hover { FONT-WEIGHT: normal; FONT-SIZE: 10px; TEXT-TRANSFORM: uppercase; COLOR: = #cc6600; FONT-FAMILY: Verdana, Arial, San Serif; TEXT-DECORATION: none } .smallteal { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #057778; FONT-FAMILY: = Verdana, Arial, San Serif } .smallteal B { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #057778; FONT-FAMILY: = Verdana, Arial, San Serif } .smalldarkteal { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #5e9da7; FONT-FAMILY: = Verdana, Arial, San Serif } .smalldarkteal B { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #5e9da7; FONT-FAMILY: = Verdana, Arial, San Serif } .smalldarkerteal { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #507f85; FONT-FAMILY: = Verdana, Arial, San Serif } .smalldarkerteal B { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #507f85; FONT-FAMILY: = Verdana, Arial, San Serif } .mediumdarkteal { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #5e9da7; FONT-FAMILY: = Verdana, Arial, San Serif } A.mediumteal { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #057778; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } .mediumteal { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #057778; FONT-FAMILY: = Verdana, Arial, San Serif } .mediumteal B { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #057778; FONT-FAMILY: = Verdana, Arial, San Serif } .largedarkteal { FONT-WEIGHT: normal; FONT-SIZE: 14px; COLOR: #5e9da7; FONT-FAMILY: = Verdana, Arial, San Serif } .largedarkteal B { FONT-WEIGHT: bold; FONT-SIZE: 14px; COLOR: #5e9da7; FONT-FAMILY: = Verdana, Arial, San Serif } .darkerteal { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #336b7c; FONT-FAMILY: = Verdana, Arial, San Serif } .darkerteal I { FONT-SIZE: 12px; COLOR: #336b7c; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif } .smalldarkerteal { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #336b7c; FONT-FAMILY: = Verdana, Arial, San Serif } .smalldarkerteal B { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #336b7c; FONT-FAMILY: = Verdana, Arial, San Serif } .smalldarkerteal I { FONT-SIZE: 10px; COLOR: #336b7c; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif } A.smalldarkerteal { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #336b7c; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.smalldarkerteal:hover { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #336b7c; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } .largeteal { FONT-WEIGHT: normal; FONT-SIZE: 14px; COLOR: #057778; FONT-FAMILY: = Verdana, Arial, San Serif } .largeteal B { FONT-WEIGHT: bold; FONT-SIZE: 14px; COLOR: #057778; FONT-FAMILY: = Verdana, Arial, San Serif } .smallgreen { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #335c3e; FONT-FAMILY: = Verdana, Arial, San Serif } .smallgreen B { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #335c3e; FONT-FAMILY: = Verdana, Arial, San Serif } .smallgreen I { FONT-SIZE: 10px; COLOR: #335c3e; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif } .green { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #335c3e; FONT-FAMILY: = Verdana, Arial, San Serif } .green B { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #335c3e; FONT-FAMILY: = Verdana, Arial, San Serif } .green I { FONT-SIZE: 12px; COLOR: #335c3e; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif } .smalllightgreen { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #81b090; FONT-FAMILY: = Verdana, Arial, San Serif } .smalllightgreen B { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #81b090; FONT-FAMILY: = Verdana, Arial, San Serif } .smalllightgreen I { FONT-SIZE: 10px; COLOR: #81b090; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif } .smalllightblue { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #80d2ea; FONT-FAMILY: = Verdana, Arial, San Serif } A.smalllightblue { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #80d2ea; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.smalllightblue:hover { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #d38229; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.smalllightblue B { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #80d2ea; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.smalllightblue:hover B { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #d38229; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.smalllightblue I { FONT-SIZE: 10px; COLOR: #80d2ea; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.smalllightblue:hover I { FONT-SIZE: 10px; COLOR: #d38229; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } .smallblue { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #0aa5d2; FONT-FAMILY: = Verdana, Arial, San Serif } A.smallblue { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #0aa5d2; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.smallblue:hover { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #cc6600; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.smallblue B { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #0aa5d2; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.smallblue:hover B { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #cc6600; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.smallblue I { FONT-SIZE: 10px; COLOR: #0aa5d2; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.smallblue:hover I { FONT-SIZE: 10px; COLOR: #cc6600; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } .smallmedblue { FONT-WEIGHT: normal; FONT-SIZE: 11px; COLOR: #0aa5d2; FONT-FAMILY: = Verdana, Arial, San Serif } A.smallmedblue { FONT-WEIGHT: normal; FONT-SIZE: 11px; COLOR: #0aa5d2; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.smallmedblue:hover { FONT-WEIGHT: normal; FONT-SIZE: 11px; COLOR: #cc6600; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.smallmedblue B { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #0aa5d2; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.smallmedblue:hover B { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #cc6600; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.smallmedblue I { FONT-SIZE: 11px; COLOR: #0aa5d2; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.smallmedblue:hover I { FONT-SIZE: 11px; COLOR: #cc6600; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } .mediumblue { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #0aa5d2; FONT-FAMILY: = Verdana, Arial, San Serif } A.mediumblue { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #0aa5d2; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.mediumblue B { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #0aa5d2; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.mediumblue I { FONT-SIZE: 12px; COLOR: #0aa5d2; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.mediumblue:hover { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #cc6600; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.mediumblue:hover B { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #cc6600; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.mediumblue:hover I { FONT-SIZE: 12px; COLOR: #cc6600; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } .xlblue { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #0aa5d2; FONT-FAMILY: = Verdana, Arial, San Serif } A.xlblue { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #0aa5d2; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.xlblue B { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #0aa5d2; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.xlblue I { FONT-SIZE: 16px; COLOR: #0aa5d2; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.xlblue:hover { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #cc6600; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.xlblue:hover B { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #cc6600; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.xlblue:hover I { FONT-SIZE: 16px; COLOR: #cc6600; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } .mediumdarkblue { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #238dac; FONT-FAMILY: = Verdana, Arial, San Serif } A.smalldarkblue { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #238dac; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.smalldarkblue B { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #238dac; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.smalldarkblue I { FONT-SIZE: 10px; COLOR: #238dac; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.smalldarkblue:hover { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #cc6600; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.smalldarkblue:hover B { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #cc6600; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.smalldarkblue:hover I { FONT-SIZE: 10px; COLOR: #cc6600; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } .mediumdarkblue { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #238dac; FONT-FAMILY: = Verdana, Arial, San Serif } A.mediumdarkblue { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #238dac; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.mediumdarkblue B { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #238dac; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.mediumdarkblue I { FONT-SIZE: 12px; COLOR: #238dac; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.mediumdarkblue:hover { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #cc6600; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.mediumdarkblue:hover B { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #cc6600; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.mediumdarkblue:hover I { FONT-SIZE: 12px; COLOR: #cc6600; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } .serifdarkblue { FONT-WEIGHT: normal; FONT-SIZE: 18px; COLOR: #238dac; FONT-FAMILY: = Times New Roman, Times, Serif } A.serifdarkblue { FONT-WEIGHT: normal; FONT-SIZE: 18px; COLOR: #238dac; FONT-FAMILY: = Times New Roman, Times, Serif; TEXT-DECORATION: none } A.serifdarkblue B { FONT-WEIGHT: bold; FONT-SIZE: 18px; COLOR: #238dac; FONT-FAMILY: Times = New Roman, Times, Serif; TEXT-DECORATION: none } A.serifdarkblue I { FONT-SIZE: 18px; COLOR: #238dac; FONT-STYLE: italic; FONT-FAMILY: Times = New Roman, Times, Serif; TEXT-DECORATION: none } A.serifdarkblue:hover { FONT-WEIGHT: normal; FONT-SIZE: 18px; COLOR: #cc6600; FONT-FAMILY: = Times New Roman, Times, Serif; TEXT-DECORATION: none } A.serifdarkblue:hover B { FONT-WEIGHT: bold; FONT-SIZE: 18px; COLOR: #cc6600; FONT-FAMILY: Times = New Roman, Times, Serif; TEXT-DECORATION: none } A.serifdarkblue:hover I { FONT-SIZE: 18px; COLOR: #cc6600; FONT-STYLE: italic; FONT-FAMILY: Times = New Roman, Times, Serif; TEXT-DECORATION: none } .seriflgdarkblue { FONT-WEIGHT: normal; FONT-SIZE: 32px; COLOR: #238dac; LINE-HEIGHT: = 29px; FONT-FAMILY: Times New Roman, Times, Serif } A.seriflgdarkblue { FONT-WEIGHT: normal; FONT-SIZE: 32px; COLOR: #238dac; LINE-HEIGHT: = 29px; FONT-FAMILY: Times New Roman, Times, Serif; TEXT-DECORATION: none } A.seriflgdarkblue B { FONT-WEIGHT: bold; FONT-SIZE: 32px; COLOR: #238dac; LINE-HEIGHT: 29px; = FONT-FAMILY: Times New Roman, Times, Serif; TEXT-DECORATION: none } A.seriflgdarkblue I { FONT-SIZE: 32px; COLOR: #238dac; LINE-HEIGHT: 29px; FONT-STYLE: italic; = FONT-FAMILY: Times New Roman, Times, Serif; TEXT-DECORATION: none } A.seriflgdarkblue:hover { FONT-WEIGHT: normal; FONT-SIZE: 32px; COLOR: #cc6600; LINE-HEIGHT: = 29px; FONT-FAMILY: Times New Roman, Times, Serif; TEXT-DECORATION: none } A.seriflgdarkblue:hover B { FONT-WEIGHT: bold; FONT-SIZE: 32px; COLOR: #cc6600; LINE-HEIGHT: 29px; = FONT-FAMILY: Times New Roman, Times, Serif; TEXT-DECORATION: none } A.seriflgdarkblue:hover I { FONT-SIZE: 32px; COLOR: #cc6600; LINE-HEIGHT: 29px; FONT-STYLE: italic; = FONT-FAMILY: Times New Roman, Times, Serif; TEXT-DECORATION: none } .serifxldarkblue { FONT-WEIGHT: normal; FONT-SIZE: 36px; COLOR: #238dac; FONT-FAMILY: = Times New Roman, Times, Serif } A.serifxldarkblue { FONT-WEIGHT: normal; FONT-SIZE: 36px; COLOR: #238dac; FONT-FAMILY: = Times New Roman, Times, Serif; TEXT-DECORATION: none } A.serifxldarkblue B { FONT-WEIGHT: bold; FONT-SIZE: 36px; COLOR: #238dac; FONT-FAMILY: Times = New Roman, Times, Serif; TEXT-DECORATION: none } A.serifxldarkblue I { FONT-SIZE: 36px; COLOR: #238dac; FONT-STYLE: italic; FONT-FAMILY: Times = New Roman, Times, Serif; TEXT-DECORATION: none } A.serifxldarkblue:hover { FONT-WEIGHT: normal; FONT-SIZE: 36px; COLOR: #cc6600; FONT-FAMILY: = Times New Roman, Times, Serif; TEXT-DECORATION: none } A.serifxldarkblue:hover B { FONT-WEIGHT: bold; FONT-SIZE: 36px; COLOR: #cc6600; FONT-FAMILY: Times = New Roman, Times, Serif; TEXT-DECORATION: none } A.serifxldarkblue:hover I { FONT-SIZE: 36px; COLOR: #cc6600; FONT-STYLE: italic; FONT-FAMILY: Times = New Roman, Times, Serif; TEXT-DECORATION: none } .greytouthead { FONT-WEIGHT: normal; FONT-SIZE: 10px; TEXT-TRANSFORM: uppercase; COLOR: = #8f8f8f; FONT-FAMILY: Verdana, Arial, San Serif } .sciPosition { FONT-WEIGHT: normal; FONT-SIZE: 10px; TEXT-TRANSFORM: uppercase; COLOR: = #5b5b5b; FONT-FAMILY: Verdana, Arial, San Serif } .sciPosition B { FONT-WEIGHT: bold; FONT-SIZE: 10px; TEXT-TRANSFORM: uppercase; COLOR: = #5b5b5b; FONT-FAMILY: Verdana, Arial, San Serif } .sciPosition I { FONT-SIZE: 10px; TEXT-TRANSFORM: uppercase; COLOR: #5b5b5b; FONT-STYLE: = italic; FONT-FAMILY: Verdana, Arial, San Serif } A.sciPosition { FONT-WEIGHT: normal; FONT-SIZE: 10px; TEXT-TRANSFORM: uppercase; COLOR: = #5b5b5b; FONT-FAMILY: Verdana, Arial, San Serif; TEXT-DECORATION: none } A.sciPosition:hover { FONT-WEIGHT: normal; FONT-SIZE: 10px; TEXT-TRANSFORM: uppercase; COLOR: = #0aa5d2; FONT-FAMILY: Verdana, Arial, San Serif; TEXT-DECORATION: none } A.sciPosition:hover B { FONT-WEIGHT: bold; FONT-SIZE: 10px; TEXT-TRANSFORM: uppercase; COLOR: = #0aa5d2; FONT-FAMILY: Verdana, Arial, San Serif; TEXT-DECORATION: none } .smalldarkgrey { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #5b5b5b; FONT-FAMILY: = Verdana, Arial, San Serif } .smalldarkgrey I { FONT-SIZE: 10px; COLOR: #5b5b5b; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif } A.smalldarkgrey B { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #5b5b5b; FONT-FAMILY: = Verdana, Arial, San Serif } .darkgrey { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #5b5b5b; FONT-FAMILY: = Verdana, Arial, San Serif } .darkgrey B { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #5b5b5b; FONT-FAMILY: = Verdana, Arial, San Serif } .darkgrey I { FONT-SIZE: 10px; COLOR: #5b5b5b; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif } A.darkgrey { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #5b5b5b; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.darkgrey:hover { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #0aa5d2; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.darkgrey:hover B { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #0aa5d2; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } .darkgrey2 { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #5e5a55; FONT-FAMILY: = Verdana, Arial, San Serif } .darkgrey2 B { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #5e5a55; FONT-FAMILY: = Verdana, Arial, San Serif } .darkgrey2 I { FONT-SIZE: 10px; COLOR: #5e5a55; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif } A.darkgrey2 { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #5e5a55; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.darkgrey2:hover { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #5e5a55; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.darkgrey2:hover B { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #5e5a55; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } .largedarkgrey B { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #5b5b5b; FONT-FAMILY: = Verdana, Arial, San Serif } .largedarkgrey I { FONT-SIZE: 16px; COLOR: #5b5b5b; FONT-STYLE: italic; FONT-FAMILY: = Verdana, Arial, San Serif } .largedarkgrey { FONT-WEIGHT: normal; FONT-SIZE: 16px; COLOR: #5b5b5b; FONT-FAMILY: = Verdana, Arial, San Serif } .largedarkgrey { FONT-WEIGHT: normal; FONT-SIZE: 11px; COLOR: #5b5b5b; FONT-FAMILY: = Verdana, Arial, San Serif } .largedarkergrey { FONT-WEIGHT: normal; FONT-SIZE: 11px; COLOR: #353535; FONT-FAMILY: = Verdana, Arial, San Serif } .largedarkergrey I { FONT-SIZE: 11px; COLOR: #353535; FONT-FAMILY: Verdana, Arial, San Serif } A.largedarkgrey { FONT-WEIGHT: normal; FONT-SIZE: 16px; COLOR: #5b5b5b; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.largedarkgrey:hover { FONT-WEIGHT: normal; FONT-SIZE: 16px; COLOR: #0aa5d2; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } A.largedarkgrey:hover B { FONT-WEIGHT: bold; FONT-SIZE: 16px; COLOR: #0aa5d2; FONT-FAMILY: = Verdana, Arial, San Serif; TEXT-DECORATION: none } .seriflggrey { FONT-WEIGHT: normal; FONT-SIZE: 17px; COLOR: #5e5a55; FONT-FAMILY: = Times New Roman, Times, Serif } A.seriflggrey { FONT-WEIGHT: normal; FONT-SIZE: 17px; COLOR: #5e5a55; FONT-FAMILY: = Times New Roman, Times, Serif; TEXT-DECORATION: none } A.seriflggrey B { FONT-WEIGHT: bold; FONT-SIZE: 17px; COLOR: #5e5a55; FONT-FAMILY: Times = New Roman, Times, Serif; TEXT-DECORATION: none } A.seriflggrey I { FONT-SIZE: 17px; COLOR: #5e5a55; FONT-STYLE: italic; FONT-FAMILY: Times = New Roman, Times, Serif; TEXT-DECORATION: none } A.seriflggrey:hover { FONT-WEIGHT: normal; FONT-SIZE: 17px; COLOR: #5e5a55; FONT-FAMILY: = Times New Roman, Times, Serif; TEXT-DECORATION: none } A.seriflggrey:hover B { FONT-WEIGHT: bold; FONT-SIZE: 17px; COLOR: #5e5a55; FONT-FAMILY: Times = New Roman, Times, Serif; TEXT-DECORATION: none } A.seriflggrey:hover I { FONT-SIZE: 17px; COLOR: #5e5a55; FONT-STYLE: italic; FONT-FAMILY: Times = New Roman, Times, Serif; TEXT-DECORATION: none } .serifmedgrey { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #5e5a55; FONT-FAMILY: = Times New Roman, Times, Serif } A.serifmedgrey { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #5e5a55; FONT-FAMILY: = Times New Roman, Times, Serif; TEXT-DECORATION: none } A.serifmedgrey B { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #5e5a55; FONT-FAMILY: Times = New Roman, Times, Serif; TEXT-DECORATION: none } A.serifmedgrey I { FONT-SIZE: 12px; COLOR: #5e5a55; FONT-STYLE: italic; FONT-FAMILY: Times = New Roman, Times, Serif; TEXT-DECORATION: none } A.serifmedgrey:hover { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #5e5a55; FONT-FAMILY: = Times New Roman, Times, Serif; TEXT-DECORATION: none } A.serifmedgrey:hover B { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #5e5a55; FONT-FAMILY: Times = New Roman, Times, Serif; TEXT-DECORATION: none } A.serifmedgrey:hover I { FONT-SIZE: 12px; COLOR: #5e5a55; FONT-STYLE: italic; FONT-FAMILY: Times = New Roman, Times, Serif; TEXT-DECORATION: none } INPUT.search { BORDER-RIGHT: #5e5a55 1px solid; BORDER-TOP: #5e5a55 1px solid; = FONT-SIZE: 9px; PADDING-BOTTOM: 1px; BORDER-LEFT: #5e5a55 1px solid; = WIDTH: 125px; PADDING-TOP: 1px; BORDER-BOTTOM: #5e5a55 1px solid; = FONT-FAMILY: Verdana, Arial, San Serif; HEIGHT: 14px; BACKGROUND-COLOR: = #ffffff } INPUT.emailstory { BORDER-RIGHT: #5e5a55 1px solid; BORDER-TOP: #5e5a55 1px solid; = FONT-SIZE: 10px; PADDING-BOTTOM: 1px; BORDER-LEFT: #5e5a55 1px solid; = WIDTH: 180px; PADDING-TOP: 1px; BORDER-BOTTOM: #5e5a55 1px solid; = FONT-FAMILY: Verdana, Arial, San Serif; HEIGHT: 20px; BACKGROUND-COLOR: = #ffffff } INPUT.smallest { BORDER-RIGHT: #5e5a55 1px solid; BORDER-TOP: #5e5a55 1px solid; = FONT-SIZE: 10px; PADDING-BOTTOM: 1px; BORDER-LEFT: #5e5a55 1px solid; = WIDTH: 50px; PADDING-TOP: 1px; BORDER-BOTTOM: #5e5a55 1px solid; = FONT-FAMILY: Verdana, Arial, San Serif; HEIGHT: 20px; BACKGROUND-COLOR: = #ffffff } INPUT.small { BORDER-RIGHT: #5e5a55 1px solid; BORDER-TOP: #5e5a55 1px solid; = FONT-SIZE: 10px; PADDING-BOTTOM: 1px; BORDER-LEFT: #5e5a55 1px solid; = WIDTH: 125px; PADDING-TOP: 1px; BORDER-BOTTOM: #5e5a55 1px solid; = FONT-FAMILY: Verdana, Arial, San Serif; HEIGHT: 20px; BACKGROUND-COLOR: = #ffffff } INPUT.medium { BORDER-RIGHT: #5e5a55 1px solid; BORDER-TOP: #5e5a55 1px solid; = FONT-SIZE: 10px; PADDING-BOTTOM: 1px; BORDER-LEFT: #5e5a55 1px solid; = WIDTH: 152px; PADDING-TOP: 1px; BORDER-BOTTOM: #5e5a55 1px solid; = FONT-FAMILY: Verdana, Arial, San Serif; HEIGHT: 20px; BACKGROUND-COLOR: = #ffffff } INPUT.large { BORDER-RIGHT: #5e5a55 1px solid; BORDER-TOP: #5e5a55 1px solid; = FONT-SIZE: 10px; PADDING-BOTTOM: 1px; BORDER-LEFT: #5e5a55 1px solid; = WIDTH: 225px; PADDING-TOP: 1px; BORDER-BOTTOM: #5e5a55 1px solid; = FONT-FAMILY: Verdana, Arial, San Serif; HEIGHT: 20px; BACKGROUND-COLOR: = #ffffff } INPUT.largest { BORDER-RIGHT: #5e5a55 1px solid; BORDER-TOP: #5e5a55 1px solid; = FONT-SIZE: 10px; PADDING-BOTTOM: 1px; BORDER-LEFT: #5e5a55 1px solid; = WIDTH: 320px; PADDING-TOP: 1px; BORDER-BOTTOM: #5e5a55 1px solid; = FONT-FAMILY: Verdana, Arial, San Serif; HEIGHT: 20px; BACKGROUND-COLOR: = #ffffff } TEXTAREA { BORDER-RIGHT: #5e5a55 1px solid; BORDER-TOP: #5e5a55 1px solid; = FONT-SIZE: 10px; PADDING-BOTTOM: 1px; BORDER-LEFT: #5e5a55 1px solid; = PADDING-TOP: 1px; BORDER-BOTTOM: #5e5a55 1px solid; FONT-FAMILY: = Verdana, Arial, San Serif; BACKGROUND-COLOR: #ffffff } SELECT { BORDER-RIGHT: #5e5a55 1px solid; BORDER-TOP: #5e5a55 1px solid; = FONT-SIZE: 10px; PADDING-BOTTOM: 1px; BORDER-LEFT: #5e5a55 1px solid; = PADDING-TOP: 1px; BORDER-BOTTOM: #5e5a55 1px solid; FONT-FAMILY: = Verdana, Arial, San Serif; BACKGROUND-COLOR: #ffffff } .menuitem { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; = PADDING-TOP: 5px; BACKGROUND-COLOR: #ffffff } .topmenudiv { BACKGROUND-COLOR: #bdbdba } .greenlogobg { BACKGROUND-COLOR: #42a960 } .darkgreenlogobg { BACKGROUND-COLOR: #3b9455 } .darkgreenbg { BACKGROUND-COLOR: #2e8444 } .lightgreenbg { BACKGROUND-COLOR: #bed8d0 } .lightgreyborder { BACKGROUND-COLOR: #b9b7ad } .greybg { BACKGROUND-COLOR: #d3d3d3 } .darkgreybg { BACKGROUND-COLOR: #4c4843 } .whitebg { BACKGROUND-COLOR: #ffffff } SPAN.greek { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #353535; FONT-FAMILY: = Symbol; TEXT-DECORATION: none } ------=_NextPart_000_0000_01C94A56.B53370E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.hhmi.org/styles/bulletin2.css P.B { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #333333; FONT-FAMILY: = Verdana, Arial, Helvetica } P { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #333333; FONT-FAMILY: = Verdana, Arial, Helvetica } P.I { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #333333; FONT-STYLE: = italic; FONT-FAMILY: Verdana, Arial, Helvetica } P.link { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #666666; FONT-FAMILY: = Verdana, Arial, Helvetica } P.home { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #333333; FONT-FAMILY: = Verdana, Arial, Helvetica } SPAN.greek { FONT-WEIGHT: normal; FONT-SIZE: 14px; COLOR: #333333; FONT-FAMILY: = Symbol; TEXT-DECORATION: none } SPAN.greekb { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #333333; FONT-FAMILY: = Symbol; TEXT-DECORATION: none } SPAN.box { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #3c75a3; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } UL { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #222222; FONT-FAMILY: = Verdana, Arial, Helvetica } LI.maroon { FONT-WEIGHT: normal; FONT-SIZE: 12px; LIST-STYLE-IMAGE: = url(/bulletin/summer2004/images/maroon_bullet.gif); COLOR: #222222; = FONT-FAMILY: "Verdana", "Arial", "Helvetica" } UL.small { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #222222; FONT-FAMILY: = Verdana, Arial, Helvetica } LI.small { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #222222; FONT-FAMILY: = "Verdana", "Arial", "Helvetica" } BLOCKQUOTE { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #222222; FONT-FAMILY: = Verdana, Arial, Helvetica } H4 { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #cc3333; FONT-FAMILY: = Verdana, Arial, Helvetica } P H4 { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #993333; FONT-FAMILY: = Verdana, Arial, Helvetica } H3 { FONT-WEIGHT: bold; FONT-SIZE: 18px; COLOR: #666666; FONT-FAMILY: = Verdana, Arial, Helvetica } H2 { FONT-WEIGHT: bold; FONT-SIZE: 18px; COLOR: #666666; FONT-FAMILY: = Verdana, Arial, Helvetica } P.form { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #666633; FONT-FAMILY: = Verdana, Arial, Helvetica } P.deck { FONT-WEIGHT: bold; FONT-SIZE: 14px; COLOR: #cc3333; FONT-FAMILY: = Verdana, Arial, Helvetica } P.subhead { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #cc3333; FONT-FAMILY: = Verdana, Arial, Helvetica } P.bluelinkb { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #465889; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } P.bluelinkb2 { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #465889; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } SPAN.subhead { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #cc3333; FONT-FAMILY: = Verdana, Arial, Helvetica } SPAN.paragraph { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #333333; FONT-FAMILY: = Verdana, Arial, Helvetica } SPAN.smallcaps { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #333333; FONT-FAMILY: = Verdana, Arial, Helvetica } SPAN.subheadblue { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #465889; FONT-FAMILY: = Verdana, Arial, Helvetica } SPAN.subheadbluesm { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #265286; FONT-FAMILY: = Verdana, Arial, Helvetica } SPAN.P { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #333333; FONT-FAMILY: = Verdana, Arial, Helvetica } SPAN.subheadgreen { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #496618; FONT-FAMILY: = Verdana, Arial, Helvetica } SPAN.subheadtan { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #7f6c51; FONT-FAMILY: = Verdana, Arial, Helvetica } .subheadtanPOP { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #7f6c51; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } P.sidebar { FONT-WEIGHT: bold; FONT-SIZE: 13px; COLOR: #ffffff; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } SPAN.redhead { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #993333; FONT-FAMILY: = Verdana, Arial, Helvetica } SPAN.related { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #cc3333; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } SPAN.greylink { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #999999; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } SPAN.greylinka { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #343030; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } SPAN.orangelinka { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #62170d; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } SPAN.orangelinkc { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #ff5016; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } SPAN.orangelinkb { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #62170d; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } SPAN.greenlinka { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #333300; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } SPAN.redlink { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #cc3333; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } SPAN.redlinka { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #cc3333; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } SPAN.bluelinkb { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #465889; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } SPAN.bluelinkc { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #465889; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } SPAN.bluelinkd { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #465889; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } SPAN.bluelinke { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #465889; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } SPAN.redlinkb { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #cc3333; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } SPAN.bluelinka { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #465889; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } SPAN.sidebarhead { FONT-WEIGHT: normal; FONT-SIZE: 20px; TEXT-TRANSFORM: uppercase; COLOR: = #343c54; FONT-FAMILY: Arial, Helvetica; TEXT-DECORATION: none } SPAN.sidebarheada { FONT-WEIGHT: normal; FONT-SIZE: 20px; TEXT-TRANSFORM: uppercase; COLOR: = #444c64; FONT-FAMILY: Arial, Helvetica; TEXT-DECORATION: none } SPAN.box { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #3c75a3; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } SPAN.headline { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #d39c2c; FONT-FAMILY: = Verdana, Arial, Helvetica } SPAN.navyheadline { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #172454; FONT-FAMILY: = Verdana, Arial, Helvetica } SPAN.zheadline { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #b44132; FONT-FAMILY: = Verdana, Arial, Helvetica } P.nav { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #333333; FONT-FAMILY: = Verdana, Arial, Helvetica } P.nav B { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #993333; FONT-FAMILY: = Verdana, Arial, Helvetica } P.list { FONT-WEIGHT: normal; FONT-SIZE: 11px; COLOR: #333333; FONT-FAMILY: = Verdana, Arial, Helvetica } P.list B { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #333333; FONT-FAMILY: = Verdana, Arial, Helvetica } .caption { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #333333; FONT-FAMILY: = Verdana, Arial, Helvetica } P.caption2 { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #333333; FONT-FAMILY: = Verdana, Arial, Helvetica } P.credit { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #999999; FONT-FAMILY: = Verdana, Arial, Helvetica } P.credit 2 { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #999999; FONT-FAMILY: = Verdana, Arial, Helvetica } P.credit I { FONT-SIZE: 10px; COLOR: #999999; FONT-FAMILY: Verdana, Arial, Helvetica } P.headline { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #d39c2c; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } SPAN.footnote { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #333333; FONT-FAMILY: = Verdana, Arial, Helvetica } SPAN.credit { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #999999; FONT-FAMILY: = Verdana, Arial, Helvetica } SPAN.bigcap { FONT-WEIGHT: bold; FONT-SIZE: 30px; COLOR: #cc3333; FONT-FAMILY: = Verdana, Arial, Helvetica } A.bluelinka { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #465889; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } A.bluelinkb { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #465889; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } A.bluelinkc { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #465889; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } A.bluelinkd { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #465889; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } A.bluelinke { FONT-WEIGHT: bold; FONT-SIZE: 12px; COLOR: #465889; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } A.related { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #cc3333; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } A.redlink { FONT-WEIGHT: normal; FONT-SIZE: 12px; COLOR: #cc3333; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } A.redlinka { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #cc3333; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } A.redlinkb { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #cc3333; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } A.greenlinka { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #333300; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } A.orangelinka { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #62170d; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } A.orangelinkb { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #62170d; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } A.greylink { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #999999; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } A.greylinka { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #343030; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } .black { FONT-WEIGHT: normal; FONT-SIZE: 9px; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } .black B { FONT-WEIGHT: bold; FONT-SIZE: 9px; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } A.black { FONT-WEIGHT: normal; FONT-SIZE: 9px; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } A.black B { FONT-WEIGHT: bold; FONT-SIZE: 9px; COLOR: #000000; FONT-FAMILY: = Verdana, Arial, Helvetica; TEXT-DECORATION: none } P.title B { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #993333; FONT-FAMILY: = Verdana, Arial, Helvetica } P.foot { FONT-WEIGHT: normal; FONT-SIZE: 10px; COLOR: #666666; FONT-FAMILY: = Verdana, Arial, Helvetica } ------=_NextPart_000_0000_01C94A56.B53370E0 Content-Type: application/x-javascript Content-Transfer-Encoding: quoted-printable Content-Location: http://www.hhmi.org/about.js var HHMIBubble, HHMINavPop;=0A= =0A= var currentNavURL;=0A= =0A= =0A= =0A= self.onerror =3D function() {=0A= =0A= return true;=0A= =0A= }=0A= =0A= function di(id,name){=0A= =0A= if (document.images) {document.images[id].src=3Deval(name+".src"); }=0A= =0A= }=0A= =0A= =0A= =0A= // function that displays status bar message=0A= =0A= =0A= =0A= function dm(msgStr) {=0A= =0A= document.returnValue =3D false;=0A= =0A= if (document.images) { =0A= =0A= window.status =3D msgStr;=0A= =0A= document.returnValue =3D true;=0A= =0A= }=0A= =0A= }=0A= =0A= var showMsg =3D navigator.userAgent !=3D "Mozilla/4.0 (compatible; MSIE = 4.0; Mac_PowerPC)";=0A= =0A= function dmim(msgStr) {=0A= =0A= document.returnValue =3D false;=0A= =0A= if (showMsg) { =0A= =0A= window.status =3D msgStr;=0A= =0A= document.returnValue =3D true;=0A= =0A= }=0A= =0A= }=0A= =0A= =0A= =0A= function setNav(navURL) {=0A= =0A= if (navURL !=3D currentNavURL) {=0A= =0A= parent.nav.location.href=3DnavURL;=0A= =0A= }=0A= =0A= }=0A= =0A= =0A= =0A= function setContent(contentURL) {=0A= =0A= parent.content.location.href=3DcontentURL;=0A= =0A= }=0A= =0A= =0A= =0A= /*=0A= =0A= // function that safely loads the main window with URL and closes the = current bubble=0A= =0A= function burstBubble(URL) {=0A= =0A= if ((HHMIBubble !=3D undefined) && (HHMIBubble.close !=3D undefined)) {=0A= =0A= if (HHMIBubble.opener) {=0A= =0A= HHMIBubble.opener.location =3D URL;=0A= =0A= HHMIBubble.close();=0A= =0A= }=0A= =0A= }=0A= =0A= }=0A= =0A= */=0A= =0A= =0A= =0A= // function that will load the bubble with URL, opening the bubble if = necessary (one bubble per page)=0A= =0A= function loadBubble(URL) {=0A= self.name =3D "hhmiabout";=0A= HHMIBubble =3D window.open(URL, window.name+'bubble', = 'toolbar=3D0,location=3D0,directories=3D0,status=3D0,scrollbars=3D1,resiz= able=3Dyes,width=3D468,height=3D560'); =0A= HHMIBubble.focus();=0A= =0A= =0A= }=0A= =0A= =0A= =0A= // function that safely closes the bubble=0A= =0A= function closeBubble() {=0A= =0A= if ((HHMIBubble !=3D undefined) && (HHMIBubble.close !=3D undefined)) {=0A= =0A= HHMIBubble.close();=0A= =0A= }=0A= =0A= }=0A= =0A= =0A= =0A= // function that (re)opens a navpop with URL (one navpop per page)=0A= =0A= function loadNavPop(URL) {=0A= =0A= HHMINavPop =3D window.open(URL, window.name+'navpop', = 'toolbar=3D0,location=3D0,directories=3D0,status=3D0,scrollbars=3D1,resiz= able=3Dno,width=3D340,height=3D350'); =0A= =0A= HHMINavPop.focus();=0A= =0A= }=0A= =0A= =0A= =0A= // function that safely loads and focuses on the main window with URL=0A= =0A= function loadMain(URL) {=0A= =0A= if (window.opener) {=0A= =0A= window.opener.location =3D URL;=0A= =0A= window.opener.focus();=0A= =0A= }=0A= =0A= }=0A= =0A= ------=_NextPart_000_0000_01C94A56.B53370E0 Content-Type: application/x-javascript Content-Transfer-Encoding: quoted-printable Content-Location: http://www.hhmi.org/js/about.js var HHMIBubble, HHMINavPop;=0A= =0A= var currentNavURL;=0A= =0A= =0A= =0A= self.onerror =3D function() {=0A= =0A= return true;=0A= =0A= }=0A= =0A= function di(id,name){=0A= =0A= if (document.images) {document.images[id].src=3Deval(name+".src"); }=0A= =0A= }=0A= =0A= =0A= =0A= // function that displays status bar message=0A= =0A= =0A= =0A= function dm(msgStr) {=0A= =0A= document.returnValue =3D false;=0A= =0A= if (document.images) { =0A= =0A= window.status =3D msgStr;=0A= =0A= document.returnValue =3D true;=0A= =0A= }=0A= =0A= }=0A= =0A= var showMsg =3D navigator.userAgent !=3D "Mozilla/4.0 (compatible; MSIE = 4.0; Mac_PowerPC)";=0A= =0A= function dmim(msgStr) {=0A= =0A= document.returnValue =3D false;=0A= =0A= if (showMsg) { =0A= =0A= window.status =3D msgStr;=0A= =0A= document.returnValue =3D true;=0A= =0A= }=0A= =0A= }=0A= =0A= =0A= =0A= function setNav(navURL) {=0A= =0A= if (navURL !=3D currentNavURL) {=0A= =0A= parent.nav.location.href=3DnavURL;=0A= =0A= }=0A= =0A= }=0A= =0A= =0A= =0A= function setContent(contentURL) {=0A= =0A= parent.content.location.href=3DcontentURL;=0A= =0A= }=0A= =0A= =0A= =0A= /*=0A= =0A= // function that safely loads the main window with URL and closes the = current bubble=0A= =0A= function burstBubble(URL) {=0A= =0A= if ((HHMIBubble !=3D undefined) && (HHMIBubble.close !=3D undefined)) {=0A= =0A= if (HHMIBubble.opener) {=0A= =0A= HHMIBubble.opener.location =3D URL;=0A= =0A= HHMIBubble.close();=0A= =0A= }=0A= =0A= }=0A= =0A= }=0A= =0A= */=0A= =0A= =0A= =0A= // function that will load the bubble with URL, opening the bubble if = necessary (one bubble per page)=0A= =0A= function loadBubble(URL) {=0A= self.name =3D "hhmiabout";=0A= HHMIBubble =3D window.open(URL, window.name+'bubble', = 'toolbar=3D0,location=3D0,directories=3D0,status=3D0,scrollbars=3D1,resiz= able=3Dyes,width=3D468,height=3D560'); =0A= HHMIBubble.focus();=0A= }=0A= =0A= // function that will load the bubble with URL, opening the bubble if = necessary) =0A= =0A= function loadFigaBubble(URL) {=0A= self.name =3D "hhminews";=0A= HHMIStoreBubble =3D window.open(URL, window.name+'bubble', = 'toolbar=3Dno,location=3Dno,directories=3Dno,status=3Dno,scrollbars=3Dyes= ,resizable=3Dyes,width=3D420,height=3D650'); =0A= HHMIStoreBubble.focus(); =0A= =0A= }=0A= =0A= // function that will load the bubble with URL, opening the bubble if = necessary (one bubble per page)=0A= =0A= function loadWideBubble(URL) {=0A= self.name =3D "hhmiabout";=0A= HHMIBubble =3D window.open(URL, window.name+'bubble', = 'toolbar=3D0,location=3D0,directories=3D0,status=3D0,scrollbars=3D1,resiz= able=3Dyes,width=3D640,height=3D440'); =0A= HHMIBubble.focus();=0A= }=0A= =0A= // function that will load the bubble with URL, opening the bubble if = necessary (one bubble per page)=0A= =0A= function loadHrBubble(URL) {=0A= self.name =3D "hhmiabout";=0A= HHMIBubble =3D window.open(URL, window.name+'bubble', = 'toolbar=3D0,location=3D0,directories=3D0,status=3D0,scrollbars=3D0,resiz= able=3Dyes,width=3D350,height=3D480'); =0A= HHMIBubble.focus(); =0A= =0A= }=0A= =0A= // function that will load the bubble with URL, opening the bubble if = necessary) =0A= =0A= function load750Bubble(URL) {=0A= self.name =3D "hhminews";=0A= HHMIStoreBubble =3D window.open(URL, window.name+'bubble', = 'toolbar=3Dno,location=3Dno,directories=3Dno,status=3Dno,scrollbars=3Dyes= ,resizable=3Dyes,width=3D750,height=3D450'); =0A= HHMIStoreBubble.focus(); =0A= }=0A= =0A= =0A= // function that will load the bubble with URL, opening the bubble if = necessary (one bubble per page)=0A= =0A= function load755Bubble(URL) {=0A= self.name =3D "hhmiabout";=0A= HHMIBubble =3D window.open(URL, window.name+'bubble', = 'toolbar=3D0,location=3D0,directories=3D0,status=3D0,scrollbars=3D1,resiz= able=3Dyes,width=3D755,height=3D705'); =0A= HHMIBubble.focus(); =0A= =0A= }=0A= =0A= // function that will load the bubble with URL, opening the bubble if = necessary (one bubble per page)=0A= =0A= function load940Bubble(URL) {=0A= self.name =3D "hhmiabout";=0A= HHMIBubble =3D window.open(URL, window.name+'bubble', = 'toolbar=3D0,location=3D0,directories=3D0,status=3D0,scrollbars=3Dauto,re= sizable=3Dyes,width=3D940,height=3D650'); =0A= HHMIBubble.focus();=0A= }=0A= =0A= // function that will load the bubble with URL, opening the bubble if = necessary (one bubble per page)=0A= =0A= function loadNavBubble(URL) {=0A= self.name =3D "hhmiabout";=0A= HHMIBubble =3D window.open(URL, window.name+'bubble', = 'toolbar=3Dyes,location=3D0,directories=3D0,status=3D0,scrollbars=3D1,res= izable=3Dyes,width=3D600,height=3D570'); =0A= HHMIBubble.focus();=0A= }=0A= =0A= // function that will load the bubble with URL, opening the bubble if = necessary (one bubble per page)=0A= =0A= function load525Bubble(URL) {=0A= self.name =3D "hhmiabout";=0A= HHMIBubble =3D window.open(URL, window.name+'bubble', = 'toolbar=3D0,location=3D0,directories=3D0,status=3D0,scrollbars=3D1,resiz= able=3Dyes,width=3D525,height=3D525'); =0A= HHMIBubble.focus();=0A= }=0A= =0A= function load550Bubble(URL) {=0A= self.name =3D "hhmiabout";=0A= HHMIBubble =3D window.open(URL, window.name+'bubble', = 'toolbar=3D0,location=3D0,directories=3D0,status=3D0,scrollbars=3D1,resiz= able=3Dyes,width=3D550,height=3D750'); =0A= HHMIBubble.focus();=0A= }=0A= =0A= // function that safely closes the bubble=0A= =0A= function load630sqBubble(URL) {=0A= self.name =3D "hhmiabout";=0A= HHMIBubble =3D window.open(URL, window.name+'bubble', = 'toolbar=3D0,location=3D0,directories=3D0,status=3D0,scrollbars=3D0,resiz= able=3Dyes,width=3D630,height=3D630'); =0A= HHMIBubble.focus();=0A= }=0A= =0A= function load660sqBubble(URL) {=0A= self.name =3D "hhmiabout";=0A= HHMIBubble =3D window.open(URL, window.name+'bubble', = 'toolbar=3D0,location=3D0,directories=3D0,status=3D0,scrollbars=3D0,resiz= able=3Dyes,width=3D660,height=3D660'); =0A= HHMIBubble.focus();=0A= }=0A= =0A= function load680rectBubble(URL) {=0A= self.name =3D "hhmiabout";=0A= HHMIBubble =3D window.open(URL, window.name+'bubble', = 'toolbar=3D0,location=3D0,directories=3D0,status=3D0,scrollbars=3D1,resiz= able=3Dyes,width=3D680,height=3D800'); =0A= HHMIBubble.focus();=0A= }=0A= =0A= function load330Bubble(URL) {=0A= self.name =3D "hhmiabout";=0A= HHMIBubble =3D window.open(URL, window.name+'bubble', = 'toolbar=3D0,location=3D0,directories=3D0,status=3D0,scrollbars=3D1,resiz= able=3Dyes,width=3D330,height=3D540'); =0A= HHMIBubble.focus();=0A= }=0A= =0A= function loadAudioBubble(URL) {=0A= self.name =3D "hhmiabout";=0A= HHMIBubble =3D window.open(URL, window.name+'bubble', = 'toolbar=3D0,location=3D0,directories=3D0,status=3D0,scrollbars=3D1,resiz= able=3Dyes,width=3D330,height=3D50'); =0A= HHMIBubble.focus();=0A= }=0A= =0A= function loadVideoBubble(URL) {=0A= self.name =3D "hhmiabout";=0A= HHMIBubble =3D window.open(URL, window.name+'bubble', = 'toolbar=3D0,location=3D0,directories=3D0,status=3D0,scrollbars=3D1,resiz= able=3Dyes,width=3D350,height=3D300'); =0A= HHMIBubble.focus();=0A= }=0A= =0A= // function that safely closes the bubble=0A= =0A= function closeBubble() {=0A= =0A= if ((HHMIBubble !=3D undefined) && (HHMIBubble.close !=3D undefined)) {=0A= =0A= HHMIBubble.close();=0A= =0A= }=0A= =0A= }=0A= =0A= =0A= =0A= // function that (re)opens a navpop with URL (one navpop per page)=0A= =0A= function loadNavPop(URL) {=0A= =0A= HHMINavPop =3D window.open(URL, window.name+'navpop', = 'toolbar=3D0,location=3D0,directories=3D0,status=3D0,scrollbars=3D1,resiz= able=3Dno,width=3D340,height=3D350'); =0A= =0A= HHMINavPop.focus();=0A= =0A= }=0A= =0A= =0A= =0A= // function that safely loads and focuses on the main window with URL=0A= =0A= function loadMain(URL) {=0A= =0A= if (window.opener) {=0A= =0A= window.opener.location =3D URL;=0A= =0A= window.opener.focus();=0A= =0A= }=0A= =0A= }=0A= =0A= ------=_NextPart_000_0000_01C94A56.B53370E0 Content-Type: application/x-javascript Content-Transfer-Encoding: quoted-printable Content-Location: http://www.hhmi.org/js/fsrscripts/triggerParams.js // Customer: Howard Hughes Medical Institute // Version : DHTML Trigger 3.2.3 function cppUrlPatch(s) { var translated =3D ""; var i;=20 var found =3D 0; for(i =3D 0; (found =3D s.indexOf(':', found)) !=3D -1; ) { translated +=3D s.substring(i, found) + "|"; i =3D found + 1; found++; } translated +=3D s.substring(i, s.length); return translated; } var triggerParms =3D new Array();=20 var excludeList =3D new Array(); var flashTagList=3D new Array(); triggerParms["displayMode"] =3D 1; //0=3Ddisable, 1=3Ddefault popup then = dhtml, 2=3Dpopup only, 3=3Ddhtml only triggerParms["mid"] =3D "M5IwhphcNVF0sgldxBpo1Q=3D=3D"; // model = instance id triggerParms["cid"] =3D "45lo1FZhVxBAhk4MYpFcRw=3D=3D"; // customer id triggerParms["lf"] =3D 4; // loyalty factor triggerParms["sp"] =3D 9; // sample percentage triggerParms["npc"] =3D 0; // no persistent cookies if 1 triggerParms["rw"] =3D 129600; // resample wait (value in minutes) triggerParms["pu"] =3D 0; // pop-under control triggerParms["olpu"] =3D 1; // On Load pop-under control triggerParms["lfcookie"] =3D "ForeseeLoyalty_MID_M5IwhphcNV"; triggerParms["ascookie"] =3D "ForeseeSurveyShown_M5IwhphcNV"; triggerParms["width"] =3D 450; // survey width triggerParms["height"] =3D 500; // survey height triggerParms["domain"] =3D ".hhmi.org"; // domain name triggerParms["omb"] =3D "1505-0186"; // OMB number //triggerParms["cmetrics"] =3D "90010257"; // coremetrics client id triggerParms["visualScienceId"] =3D 0; // enable visual science code if = 1 triggerParms["omnitureId"] =3D 0; // enable omniture code if 1 triggerParms["cpp_1"] =3D "userURL:" + cppUrlPatch = (window.location.href); //triggerParms["cpp_5"] =3D "cpp_name:"+ cppUrlPatch("cpp_value"); //a = placeholder for customer CPP's triggerParms["capturePageView"] =3D 1; //excludeList[0] =3D "/exclude/"; //trigger script will not work under = this path //triggerParms["dcUniqueId"] =3D "TEST04JloZZN0k9cI1Ep5d"; // (22 chars = unique Id for double cookie I/II) //triggerParms["midexp"] =3D 129600; // model instance expiry value triggerParms["rso"]=3D 0; //user has chosen to use Retry Survey Option triggerParms["aro"]=3D 0; //user has chosen to use Auto Retry Option, = with SP=3D100 //triggerParms["rct"]=3D 1; //The maximum number of times allowed to = serve a survey to a user //triggerParms["rds"]=3D 1; //The minimum number of days to wait to = serve a survey repeatedly //triggerParms["mrd"]=3D 1; //The total number of days that a user can = be re-served a survey triggerParms["compliant508"] =3D 1; //508 compliant if 1 //DHTML Parameters triggerParms["dhtmlIndex"]=3D 100; // z-index s/b greater then = client=92s dhtml z-index (if exist) - default 100 triggerParms["dhtmlWidth"] =3D 400; // welcome page width triggerParms["dhtmlHeight"] =3D 290; // welcome page height triggerParms["dhtmlURL"]=3D "/js/fsrscripts/FSRInvite.html"; //DHTML Positioning //center bottom-center bottom-right bottom-left upper-right = upper-left //x,y =3D (2,150) x,y =3D (2,350) x,y =3D (1.02,350) x,y =3D (60,350) = x,y =3D (1.02,50) x,y =3D (60,50) //replace (x,y) below with any one of the above, default =3D center var x=3D2; var y=3D150; triggerParms["dhtmlLeft"] =3D (self.screen.width - = triggerParms["dhtmlWidth"])/x; //invite page left position**DO NOT = MODIFY** triggerParms["dhtmlTop"] =3D Math.min((self.screen.height - = triggerParms["dhtmlHeight"])/2,y); //invite page top position**DO NOT = MODIFY** //FLASH Parameters - not to be used with other embedded objects e.g. = (.dcr/.mov/.mpeg/.avi/.wma/.wmv/.aam/.rm/.ram) triggerParms["flashDetect"]=3D 0; // check if page has flash embedded = with a valid browser & player ver before showing dhtml - disable if 0 flashTagList[0]=3D "swf"; // flash src check for IE/NE complaint = browsers flashTagList[1]=3D "spl"; // splash src check for IE/NE complaint = browsers flashTagList[2]=3D "clsid:d27cdb6e-ae6d-11cf-96b8-444553540000"; = //activeX ID check for IE browsers only triggerParms["inviteDelay"]=3D 1000; // invite timeout in millisecs - = default 1000ms=3D1sec //List of Multiple Survey Vendors - uncomment variables below & add = corresponding SP and URL //var multiVendorSP=3D new Array(); //var multiVendorURL=3D new Array(); //multiVendorSP[0] =3D 0; // sampling percentage for another vendor - = disable if commented //multiVendorURL[0] =3D ""; // absolute path to the third-party script - = disable if commented //Foresee System Paramters triggerParms["captureTriggerVersion"] =3D "STD3.2.3"; // track latest = trigger version triggerParms["popupURL"] =3D "//www.foreseeresults.com/survey/display"; = //do not change this url unless notified. triggerParms["FSRImgURL"]=3D "//www.foreseeresults.com/survey/FSRImg"; = //do not change this url unless notified. ------=_NextPart_000_0000_01C94A56.B53370E0 Content-Type: application/x-javascript Content-Transfer-Encoding: quoted-printable Content-Location: http://www.hhmi.org/js/fsrscripts/stdLauncher.js /************ don't modify below this line ********* ************* = Version : DHTML Trigger 3.2.3 ****** ****** Copyright 2001-2006 = ForeseeResults, Inc****/ var OTCImgURL =3D = "//controller.foreseeresults.com/fsrSurvey/OTCImg"; var ckAlreadyShown = =3D triggerParms["ascookie"]; /* name of the persistent/session cookie*/ = var ckLoyaltyCount =3D triggerParms["lfcookie"]; /* name of the loyalty = count cookie*/ var fullURL=3Dnull; var myPopUp=3Dnull; var = fsr_mac=3Dnull; var fsr_aol=3Dnull; var fsr_opera=3Dnull; var = fsr_NS8=3Dnull; /*used in Invite Page to show Note for Netscape 8 = browsers only*/ var fsr_ie=3D0; var flash_version=3D 4; /*supports flash = version 4 and above in IE only*/ var canFlashPlay=3D0; var = dcQString=3D""; var cpp_3 =3D ""; var winOptions =3D = "toolbar=3D0,scrollbars=3D1,location=3D0,statusbar=3D0,menubar=3D0,resiza= ble=3D1,width=3D1,height=3D1,top=3D4000,left=3D4000"; var = persistentExpires =3D new Date(); /*persistent cookie expiration*/ = persistentExpires.setTime(persistentExpires.getTime() + = (triggerParms["rw"]*60*1000)); var detect =3D = navigator.userAgent.toLowerCase(); var version=3D = navigator.appVersion.toLowerCase(); /* FOR MSIE BASED BROWSERS ONLY - = detect Flash Plugin & Version*/ if (detect && = detect.indexOf("msie")>=3D0 && (version.indexOf("win") !=3D -1) && = triggerParms["flashDetect"] =3D=3D 1) { fsr_ie=3D1; = document.write(' \n'); = document.write('on error resume next \n'); document.write('canFlashPlay = =3D ( IsObject(CreateObject("ShockwaveFlash.ShockwaveFlash." & = flash_version)))\n'); document.write(' \n'); } function = ForeCStdGetCookie (name) { var arg =3D name + "=3D"; var alen =3D = arg.length; var clen =3D document.cookie.length; var i =3D 0; while (i < = clen) { var j =3D i + alen; if (document.cookie.substring(i, j) =3D=3D = arg) { return ForeCStdGetCookieVal (j); } i =3D = document.cookie.indexOf(" ", i) + 1; if (i =3D=3D 0) { break; } } return = null; } function fsr_showWindow() { if(myPopUp !=3D null && = !myPopUp.closed && fsr_aol=3D=3Dfalse && fsr_opera=3D=3Dfalse) {return;} = var cpp3Str =3D ""; cpp_3 =3D "Browser:"+ cppUrlPatch (detect) + ";" + = triggerParms["captureTriggerVersion"]; cpp_3+=3D";dhtml"; var pos1 =3D = fullURL.indexOf("&cpp_3=3D"); var pos2 =3D fullURL.indexOf("&",pos1+1); = if (pos2=3D=3D-1){ fullURL =3D fullURL.substring(0,pos1); }else{ cpp3Str = =3D fullURL.substring(pos2,fullURL.length); fullURL =3D = fullURL.substring(0,pos1); } fullURL+=3D"&cpp_3=3D"+cpp_3 + cpp3Str; = if(document.all && document.all.fsr_window.filters) { = eval("document.all.fsr_window").filters.revealTrans.transition =3D 23 ; = eval("document.all.fsr_window").filters.revealTrans.Apply(); = eval("document.all.fsr_window").style.visibility =3D 'visible'; = eval("document.all.fsr_window").filters.revealTrans.Play(); } else = if(document.all) {document.all.fsr_window.style.visibility =3D = 'visible';} else if(document.getElementById) = {document.getElementById("fsr_window").style.visibility =3D 'visible';} = } function fsr_hideWindow() { if(document.all && = document.all.fsr_window.filters) { = eval("document.all.fsr_window").filters.revealTrans.transition =3D 23; = eval("document.all.fsr_window").filters.revealTrans.Apply(); = eval("document.all.fsr_window").style.visibility =3D 'hidden'; = eval("document.all.fsr_window").filters.revealTrans.Play(); } else = if(document.all) {document.all.fsr_window.style.visibility =3D = 'hidden';} else if(document.getElementById) = {document.getElementById("fsr_window").style.visibility =3D 'hidden';} } = function ForeCStdSetCookie (name, value) { var argv =3D = ForeCStdSetCookie.arguments; var argc =3D = ForeCStdSetCookie.arguments.length; var expires =3D (argc > 2) ? argv[2] = : null; var path =3D (argc > 3) ? argv[3] : null; var domain =3D (argc > = 4) ? argv[4] : null; var secure =3D (argc > 5) ? argv[5] : false; = document.cookie =3D name + "=3D" + escape (value) + ((expires =3D=3D = null) ? "" : ("; expires=3D" + expires.toGMTString())) + ((path =3D=3D = null) ? "" : ("; path=3D" + path)) + ((domain =3D=3D null) ? "" : ("; = domain=3D" + domain)) + ((secure =3D=3D true) ? "; secure" : ""); } = function ForeCStdGetCookieVal(offset) { var endstr =3D = document.cookie.indexOf (";", offset); if (endstr =3D=3D -1) { endstr = =3D document.cookie.length; } return = unescape(document.cookie.substring(offset, endstr)); } function = specialEscape(str) { var translated =3D ""; var i; var found =3D 0; = for(i =3D 0; (found =3D str.indexOf('+', found)) !=3D -1; ) { translated = +=3D str.substring(i, found) + "%2B"; i =3D found + 1; found++; } = translated +=3D str.substring(i, str.length); return translated; } = function Pop(){ myPopUp =3D window.open(fullURL, "survey",winOptions); = if ( myPopUp!=3Dnull && !myPopUp.closed) { if (triggerParms["pu"] =3D=3D = 1){self.focus(); } else { myPopUp.focus(); } } } function = currentLocationExcluded() { var parentURLPath =3D = window.location.pathname;/*location path*/ for(key in excludeList) { = if(parentURLPath.indexOf(excludeList[key]) !=3D -1) { return true; } } = return false; } var newDt; var currTime; /*in millisecs*/ var OTCImg; = var FSRImg; var surveyProcessCont =3D 1; function stdImgProc() { = if(triggerParms["compliant508"] =3D=3D 1) { fsr_showWindow();} else { = setTimeout("fsr_showWindow();", = triggerParms["inviteDelay"],"JavaScript"); } } function fsrShowSurvey(){ = if(dcQString =3D=3D "") { stdImgProc(); } else { newDt =3D new Date(); = currTime=3D newDt.getTime(); /*in millisecs*/ FSRImg =3D new Image(); = FSRImg.src =3D null; FSRImg.onerror =3D imgErrorProc; FSRImg.onload =3D = imgOnloadProc; FSRImg.src =3D triggerParms["FSRImgURL"] + "?" + = dcQString + "&uid=3D"+ currTime; /*for NE/FF Cache Fix*/ } } function = imgOnloadProc() { if(surveyProcessCont =3D=3D 1 && FSRImg.width =3D=3D = 3) { stdImgProc(); } return true; } function imgErrorProc() { = surveyProcessCont =3D 0; return true; } function otcOnloadProc() { = if(surveyProcessCont =3D=3D 1 && OTCImg.width =3D=3D 3) { = fsrShowSurvey(); } else { surveyProcessCont =3D 0; } return true; } = function otcErrorProc() { fsrShowSurvey(); return true; } function = setVisualSciencesId(theURL) { var VisualSciencesId =3D = ForeCStdGetCookie("v1st"); if(VisualSciencesId !=3D null && = VisualSciencesId !=3D "") { triggerParms["cpp_4"] =3D = "VisualSciencesId:" + escape(VisualSciencesId); } } function = setOmnitureId(theURL) { var OmnitureId =3D = ForeCStdGetCookie("s_foreSeeId"); if(OmnitureId !=3D null && OmnitureId = !=3D "") { triggerParms["cpp_0"] =3D "OmnitureId:" + escape(OmnitureId); = } } function checkFlashParms(tagName){ tagName =3D = tagName.toLowerCase(); for(key in flashTagList) { = if(tagName.indexOf(flashTagList[key]) !=3D -1) { return true; } } return = false; } function fsr_detectFlash(){ if (fsr_ie){ /** For IE Compatible = browsers **/ var obj =3D document.all.tags("OBJECT"); for (var e=3D0; = e=3D0) ? 1 : 0; var = fsr_NS =3D ((detect.indexOf("netscape") >=3D0) || = (detect.indexOf("firefox") >=3D0)) ? 1 : 0; if (fsr_NS) = flash_version=3D7; /*Netscape Mozilla supports flash player 7 and = above*/ if (fsr_mac) flash_version=3D8; /*Mac Browsers supports flash = player 8 and above*/ /** FOR MOZILLA BASED BROWSERS - detect flash = plugin & version **/ var = plugin=3D(navigator.mimeTypes&&navigator.mimeTypes["application/x-shockwa= ve-flash"]?navigator.mimeTypes["application/x-shockwave-flash"].enabledPl= ugin:0); if (plugin && = parseInt(plugin.description.substring(plugin.description.indexOf(".")-1))= >=3Dflash_version) { canFlashPlay=3D1; } if ((plugin =3D=3D0 || = plugin=3D=3Dnull) && !canFlashPlay){ triggerParms["displayMode"]=3D1; } = else { /** Skip dhtml invite for the following browsers: ** For Opera = ver 7.5 and below and ** All Netscape Browsers with flash ver < 7 ** Mac = Browsers with flash 7 and below ** Reason: possible bug in browser or = with flash player using wmode ** ** Show Flash for all other browsers = with flash >=3D4 ** Supports IE5+,AOL7+,AOLExplorer,MAC,OPERA8+,FF,NS7+ = **/ if ((fsr_NS && canFlashPlay) || (!fsr_opera75 && canFlashPlay)){ if = (triggerParms["displayMode"]=3D=3D1){ return true; } } = triggerParms["displayMode"]=3D2; } } } if (triggerParms["displayMode"] = >0){ triggerParms["inviteDelay"]=3D 1000; /*overwrite invite timeout to = 1 sec*/ return true; } return false; } function isAlreadyShown(){ = /*check if we already have shown survey or OE Scout Tracker has been = closed*/ if (ForeCStdGetCookie(ckAlreadyShown) !=3D null || = (ForeCStdGetCookie("ScoutRunningCheck") !=3Dnull && = ForeCStdGetCookie("ScoutRunningCheck") =3D=3D "ScoutClosed")) return = true; return false; } function Poll() { if(triggerParms["displayMode"] = =3D=3D 0) { return; } if(currentLocationExcluded()) { return; } var = stickyCounter =3D ForeCStdGetCookie(ckLoyaltyCount); /*check counter = cookie*/ var pageCount; var randNum =3D Math.random(); randNum *=3D 100; = if (stickyCounter =3D=3D null) { pageCount =3D 1; = ForeCStdSetCookie(ckLoyaltyCount, pageCount, = null,'/',triggerParms["domain"]); stickyCounter =3D = ForeCStdGetCookie(ckLoyaltyCount); } if (stickyCounter !=3D null) { = pageCount =3D stickyCounter; if(pageCount >=3D triggerParms["lf"]) { = if(!isAlreadyShown()) { if (triggerParms["rso"] =3D=3D 1 && = triggerParms["aro"] =3D=3D 1) { triggerParms["sp"] =3D 100.0; /*Update = Sample percentage*/ } if(randNum <=3D triggerParms["sp"]) { fsr_aol=3D = ((detect.indexOf("aol") >=3D0) || (detect.indexOf("america online = browser") >=3D0)) ? 1 : 0; fsr_opera =3D (detect.indexOf("opera") >=3D0) = ? 1 : 0; fsr_mac=3D (navigator.platform.indexOf("Win32") >=3D 0) ? 0 : = 1; fsr_NS8=3D(detect.indexOf("netscape/8") >=3D0) ? 1 : 0; = fsr_browser=3D"fsr_nn6"; if(document.all || document.getElementById){ = fsr_browser =3D "fsr_ie"; } if(document.layers) { fsr_browser =3D = "fsr_nn"; } fullURL =3D triggerParms["popupURL"] + "?" + "width=3D" + = triggerParms["width"] + "&height=3D" + triggerParms["height"] + = "&cid=3D" + specialEscape(escape(triggerParms["cid"])) + "&mid=3D" + = specialEscape(escape(triggerParms["mid"])); if ((triggerParms["omb"] ) = !=3D null) { fullURL +=3D "&omb=3D" + escape(triggerParms["omb"]); } if = ((triggerParms["cmetrics"] ) !=3D null) { fullURL +=3D "&cmetrics=3D" + = escape(triggerParms["cmetrics"]); } if (triggerParms["olpu"] =3D=3D 1) { = fullURL +=3D "&olpu=3D1"; } if ((triggerParms["dcUniqueId"]) !=3D null) = { fullURL +=3D "&dcUniqueId=3D" + escape(triggerParms["dcUniqueId"]); } = if (triggerParms["rso"] =3D=3D 1) { fullURL +=3D "&rso=3D1&rct=3D" + = triggerParms["rct"] + "&rds=3D" + triggerParms["rds"] + "&mrd=3D" + = triggerParms["mrd"] + "&rws=3D" + triggerParms["rw"]; } if = ((triggerParms["midexp"] ) !=3D null) { fullURL +=3D = "&ndc=3D1&fsexp=3D5256000&midexp=3D" + triggerParms["midexp"]; } if = (triggerParms["capturePageView"] =3D=3D 1) { triggerParms["cpp_2"] =3D = "PageView:"+ pageCount; /*customer parameter 2 - Page View*/ } = triggerParms["cpp_3"] =3D "Browser:"+ cppUrlPatch (detect) + ";" + = triggerParms["captureTriggerVersion"] +";normal"; if = (triggerParms["visualScienceId"] =3D=3D 1) { = setVisualSciencesId(fullURL); } if (triggerParms["omnitureId"] =3D=3D 1) = { setOmnitureId(fullURL); } var customerParams =3D ""; for(paramKey in = triggerParms) { if(paramKey.substring(0,3) =3D=3D "cpp"){ fullURL +=3D = "&"+ paramKey + "=3D" + escape(triggerParms[paramKey]); } } if = (triggerParms["rso"] !=3D 1) { if(triggerParms["npc"] =3D=3D 1) { = ForeCStdSetCookie(ckAlreadyShown, = 'true',null,'/',triggerParms["domain"]); } else { = ForeCStdSetCookie(ckAlreadyShown, 'true', = persistentExpires,'/',triggerParms["domain"]); } } /*for AOL and Opera = users - show DHTML (by default) because their PopupBlocker behaves = differently*/ if (fsr_aol=3D=3Dfalse && fsr_opera=3D=3Dfalse) { if = (triggerParms["displayMode"]=3D=3D1 || = triggerParms["displayMode"]=3D=3D2){ myPopUp =3D window.open(fullURL, = 'survey',winOptions); } } /** detect flash with valid browser and player = version**/ if (!fsr_mac && (fsr_browser !=3D "fsr_nn") && isValidFlash() = && triggerParms["displayMode"] !=3D2) { document.write("

" + "

"); /*DC I/II = verification*/ if (triggerParms["rso"] =3D=3D 1) { dcQString =3D = "rso=3D1&rct=3D" + triggerParms["rct"] + "&rds=3D" + triggerParms["rds"] = + "&mrd=3D" + triggerParms["mrd"] + "&rws=3D" + triggerParms["rw"]; = if(triggerParms["dcUniqueId"]!=3Dnull) { dcQString +=3D "&dcUniqueId=3D" = + specialEscape(escape(triggerParms["dcUniqueId"])); } } if = ((triggerParms["midexp"] ) !=3D null) { dcQString =3D = "ndc=3D1&midexp=3D" + triggerParms["midexp"] + "&mid=3D" + = specialEscape(escape(triggerParms["mid"])); = if(triggerParms["dcUniqueId"]!=3Dnull) { dcQString +=3D "&dcUniqueId=3D" = + specialEscape(escape(triggerParms["dcUniqueId"])); } } /*Failover = Check*/ surveyProcessCont =3D 1; newDt =3D new Date(); currTime=3D = newDt.getTime(); /*in millisecs*/ OTCImg =3D new Image(); OTCImg.src =3D = null; OTCImg.onerror =3D otcErrorProc; OTCImg.onload =3D otcOnloadProc; = OTCImg.src =3D OTCImgURL + "?protocol=3D" + window.location.protocol + = "&uid=3D"+ currTime; /*for NE/FF Cache Fix*/ } if(myPopUp !=3D null && = !myPopUp.closed) { if (triggerParms["pu"] =3D=3D 1){ self.focus(); } = else { myPopUp.focus();} } } } } pageCount++; = ForeCStdSetCookie(ckLoyaltyCount, pageCount, = null,'/',triggerParms["domain"]); } } ------=_NextPart_000_0000_01C94A56.B53370E0 Content-Type: application/x-javascript Content-Transfer-Encoding: quoted-printable Content-Location: http://www.hhmi.org/js/rollovers/methods.js // roll over OVER function=0A= function rollOver(imgName)=0A= {=0A= if (document.images)=0A= {=0A= document[imgName].src=3Deval(imgName + "over.src");=0A= }=0A= }=0A= =0A= // roll over ON function=0A= function rollOn(imgName)=0A= {=0A= if (document.images)=0A= {=0A= document[imgName].src=3Deval(imgName + "on.src");=0A= }=0A= }=0A= =0A= // roll over OFF function=0A= function rollOff(imgName)=0A= {=0A= if (document.images)=0A= {=0A= document[imgName].src=3Deval(imgName + "off.src");=0A= }=0A= }=0A= // -----------------------=0A= =0A= =0A= =0A= =0A= =0A= =0A= =0A= =0A= =0A= =0A= ------=_NextPart_000_0000_01C94A56.B53370E0 Content-Type: application/x-javascript Content-Transfer-Encoding: quoted-printable Content-Location: http://www.hhmi.org/js/rollovers/shared.js =0A= =0A= // Creating Images and setting up their src properties=0A= if (document.images)=0A= {=0A= =0A= // TOP NAV=0A= btnHome_over =3D new Image=0A= btnHome_over.src =3D"/images/btnHome_over.gif"=0A= btnHome_on =3D new Image=0A= btnHome_on.src =3D"/images/btnHome_on.gif"=0A= btnHome_off =3D new Image=0A= btnHome_off.src =3D"/images/btnHome_off.gif"=0A= =0A= btnAbout_over =3D new Image=0A= btnAbout_over.src =3D"/images/btnAbout_over.gif"=0A= btnAbout_on =3D new Image=0A= btnAbout_on.src =3D"/images/btnAbout_on.gif"=0A= btnAbout_off =3D new Image=0A= btnAbout_off.src =3D"/images/btnAbout_off.gif"=0A= =0A= btnPress_over =3D new Image=0A= btnPress_over.src =3D"/images/btnPress_over.gif"=0A= btnPress_on =3D new Image=0A= btnPress_on.src =3D"/images/btnPress_on.gif"=0A= btnPress_off =3D new Image=0A= btnPress_off.src =3D"/images/btnPress_off.gif"=0A= =0A= btnEmploy_over =3D new Image=0A= btnEmploy_over.src =3D"/images/btnEmploy_over.gif"=0A= btnEmploy_on =3D new Image=0A= btnEmploy_on.src =3D"/images/btnEmploy_on.gif"=0A= btnEmploy_off =3D new Image=0A= btnEmploy_off.src =3D"/images/btnEmploy_off.gif"=0A= =0A= btnContact_over =3D new Image=0A= btnContact_over.src =3D"/images/btnContact_over.gif"=0A= btnContact_on =3D new Image=0A= btnContact_on.src =3D"/images/btnContact_on.gif"=0A= btnContact_off =3D new Image=0A= btnContact_off.src =3D"/images/btnContact_off.gif"=0A= =0A= // HOME -- Context=0A= btnViewCatalog_over =3D new Image=0A= btnViewCatalog_over.src =3D"/images/btnViewCatalog_over.gif"=0A= btnViewCatalog_off =3D new Image=0A= btnViewCatalog_off.src =3D"/images/btnViewCatalog_off.gif"=0A= =0A= // HOME -- Top Nav=0A= btnHomeContext_over =3D new Image=0A= btnHomeContext_over.src =3D"/images/btnHome_over.gif"=0A= btnHomeContext_on =3D new Image=0A= btnHomeContext_on.src =3D"/images/btnHome_on.gif"=0A= btnHomeContext_off =3D new Image=0A= btnHomeContext_off.src =3D"/images/btnHomeContext_off.gif"=0A= =0A= =0A= // ABOUT -- Top Nav=0A= btnAboutContext_over =3D new Image=0A= btnAboutContext_over.src =3D"/images/btnAbout_over.gif"=0A= btnAboutContext_on =3D new Image=0A= btnAboutContext_on.src =3D"/images/btnAbout_on.gif"=0A= btnAboutContext_off =3D new Image=0A= btnAboutContext_off.src =3D"/images/btnAboutContext_off.gif"=0A= =0A= // PRESS -- Top Nav=0A= btnPressContext_over =3D new Image=0A= btnPressContext_over.src =3D"/images/btnPress_over.gif"=0A= btnPressContext_on =3D new Image=0A= btnPressContext_on.src =3D"/images/btnPress_on.gif"=0A= btnPressContext_off =3D new Image=0A= btnPressContext_off.src =3D"/images/btnPressContext_off.gif"=0A= =0A= // CONTACT -- Top Nav=0A= btnContactContext_over =3D new Image=0A= btnContactContext_over.src =3D"/images/btnContact_over.gif"=0A= btnContactContext_on =3D new Image=0A= btnContactContext_on.src =3D"/images/btnContact_on.gif"=0A= btnContactContext_off =3D new Image=0A= btnContactContext_off.src =3D"/images/btnContactContext_off.gif"=0A= =0A= // POPUP=0A= btnCloseWindow_over =3D new Image=0A= btnCloseWindow_over.src =3D"/images/btnCloseWindow_over.gif"=0A= btnCloseWindow_off =3D new Image=0A= btnCloseWindow_off.src =3D"/images/btnCloseWindow_off.gif"=0A= =0A= }=0A= =0A= // roll over OVER function=0A= function rollOver(imgName)=0A= {=0A= if (document.images)=0A= {=0A= document[imgName].src=3Deval(imgName + "over.src");=0A= }=0A= }=0A= =0A= // roll over ON function=0A= function rollOn(imgName)=0A= {=0A= if (document.images)=0A= {=0A= document[imgName].src=3Deval(imgName + "on.src");=0A= }=0A= }=0A= =0A= // roll over OFF function=0A= function rollOff(imgName)=0A= {=0A= if (document.images)=0A= {=0A= document[imgName].src=3Deval(imgName + "off.src");=0A= }=0A= }=0A= // -----------------------=0A= ------=_NextPart_000_0000_01C94A56.B53370E0 Content-Type: application/x-javascript Content-Transfer-Encoding: quoted-printable Content-Location: http://www.hhmi.org/defaults.js default_libs_path =3D "/jslib/";=0A= =0A= =0A= /* This is for Emacs' benefit:=0A= * Local Variables: ***=0A= * mode: Java ***=0A= * End: ***=0A= */=0A= ------=_NextPart_000_0000_01C94A56.B53370E0 Content-Type: application/x-javascript Content-Transfer-Encoding: quoted-printable Content-Location: http://www.hhmi.org/uni_sniff.js // end hide JavaScript=0A= ------=_NextPart_000_0000_01C94A56.B53370E0 Content-Type: application/x-javascript Content-Transfer-Encoding: quoted-printable Content-Location: http://www.hhmi.org/libloader.js /*=0A= =0A= libloader.js - load JavaScript libraries based on browser type=0A= =0A= NOTE: Requires that the "Ultimate client-side JavaScript client=0A= sniff" from Netscape (or its equivalent) be already loaded, as=0A= this makes decisions based on the sniff's results.=0A= =0A= NOTE: If you neither pass in a libs_path argument nor override=0A= default_libs_path before you call load_library, it will default to=0A= computing library filenames relative to the current path. That=0A= means that each library should have its own directory in the=0A= current path, e.g., object_access/, object_position/, etc.=0A= =0A= You probably -really- want to go ahead and set a library path, for=0A= cleanliness' sake.=0A= =0A= NOTE: If default_libs_path or a libs_path argument is non-empty,=0A= it MUST end with a slash ("/"), since I don't really want to hack=0A= around to check for that right now. Maybe later, when I'm feeling=0A= more user-friendly.=0A= =0A= NOTE: This is the one library (apart from uni_sniff, of course)=0A= that will probably have nasty, hackish, per-browser checking,=0A= because it can't rely on any generalized functionality having been=0A= loaded yet. However, I try to rely on as little mojo as possible=0A= here (get_global being the only place I'm aware of needing to=0A= abstract away anything, and that happens to be the same across all=0A= browsers right now) in an effort to keep things clean.=0A= =0A= However, note that _make_libpath has some nasty hardcoded rules to=0A= compute the library filename. Those rules are (at present)=0A= necessary because of the way uni_sniff computes its various=0A= variables. We can't just look through the namespace and snatch out=0A= "is_" variables that are true. We actually have to know something=0A= about the various quirks of how browsers are named and how=0A= compatible they are (or aren't). At some point, we'll codify this=0A= in a snazzy data structure, but that day ain't today.=0A= =0A= */=0A= =0A= // We check, just in case someone defined default_libs_path -before-=0A= // loading this script (or loaded this script multiple times?)=0A= if (! default_libs_path) var default_libs_path =3D "";=0A= =0A= =0A= /* All browsers do this the same way, so we're safe defining it here. */=0A= function get_global (name) {=0A= return window[name];=0A= }=0A= =0A= =0A= function library_loaded (name) {=0A= debug.writeln("library_loaded: " + name + " [" + get_global("lib_" + = name) + "]");=0A= return get_global("lib_" + name);=0A= }=0A= =0A= =0A= function library_load (name, libs_path) {=0A= if (library_loaded(name)) return 1;=0A= var libpath =3D _make_libpath(name, libs_path);=0A= document.write('